4th International Caparica Conference in SPLICING 2021

26th – 29th July 2021 | Caparica | Portugal

Oral Speakers

Benjamin Lee, PhD

Affiliation: University of Exeter (United Kingdom)

Title: Negligible senescence in naked mole rats may be a consequence of well-maintained splicing regulation.

Francois Bordeleau, PhD

Affiliation: CRChu de Québec (HDQ) – Universite Laval (Canada)

Title: Tumor mechanics and alternative splicing: at the crossroad between regulation and adaptation.

Alexandra Filatova, PhD

Affiliation: Research Centre of Medical Genetics, Moscow (Russia)

Title: PAX6 5’-UTR mutations affecting splicing lead to a disruption of protein translation and cause Congenital aniridia.

Corinna Giorgi, PhD

Affiliation: European Brain Research Institute (Italy)

Title: Arc 3’UTR splicing leads to dual and antagonistic effects in fine-tuning Arc expression upon BDNF signaling.

Martin Schroeder, PhD

Affiliation: Durham University (United Kingdom)

Title: An initial phase of JNK activation inhibits cell death early in the endoplasmic reticulum stress response.

Nicola Jeffery, PhD

Affiliation: University of Exeter (United Kingdom)

Title: Cellular stressors may alter islet hormone cell proportions by moderation of alternative splicing patterns.

Penelope Morel, PhD

Affiliation: University of Pittsburgh (United States)

Title: The role of RNA processing factors in regulatory T cell differentiation: does splicing matter?

Tal Shay, PhD

Affiliation: Ben-Gurion University of the Negev (Israel)

Title: The splicing program of the immune system.

Olivier Pardo, PhD

Affiliation: Imperial College (United Kingdom)

Title: hnRNPA1 promotes cancer progression in response to FGF2 signalling.

Kristel Sleegers, PhD

Affiliation: VIB-UAntwerp Center for Molecular Neurology (Belgium)

Title: Splicing of ABCA7 and risk of Alzheimer’s disease.

Julia E. Weigand, PhD

Affiliation: Technische Universität Darmstadt (Germany)

Title: Muscleblind-like 2 controls the hypoxia response of cancer cells.

Veronica Arora, PhD

Affiliation: Institute of Genetics and Genomics, Sir Ganga Ram Hospital, New Delhi (India)

Title: The first case of antenatal presentation in COG related Congenital Disorders of Glycosylation: a novel splice site mutation.

Eduardo Eyras, PhD

Affiliation: Australian National University (Australia)

Title: Unshackling transcriptomes from genome references.

Eiichi Saitoh, PhD

Affiliation: Graduate School of Technology, Niigata Institute of Technology (Japan)

Title: Expression of proline-rich proteins, P-B1, P-B, and BPLP, the parent proteins of opiorphin family, in human saliva.

Enrico Schleiff, PhD

Affiliation: Goethe University & FIAS (Germany)

Title: Splicing as central regulatory element of the plant heat stress response.

Mubeen Khan, PhD

Affiliation: Radboud university medical center, Nijmegen (Netherlands)

Title: Non-coding (splice) variants resolve the missing heritability in ABCA4-associated Stargardt disease.

Maayan Salton, PhD

Affiliation: Hebrew University (Israel)

Title: KDM3A regulates alternative splicing of cell-cycle genes following DNA damage.

Steven Fisher, PhD

Affiliation: University of Maryland School of Medicine (United States)

Title: Alternative splicing determines vascular smooth muscle function: Focus on myosin phosphatase splice variants and their targeting for therapeutic gain.

Luciana Haddad, PhD

Affiliation: Universidade de São Paulo (Brazil)

Title: Human DNA variants affecting pre-mRNA splicing: an NGS perspective.

Tracy Kress, PhD

Affiliation: The College of New Jersey (United States)

Title: Acetylation of Histones H4 and H2A.Z by the NuA4 acetyltransferase is Required for Appropriate RNA Splicing in Saccharomyces cerevisiae.

Giulia Fontemaggi, PhD

Affiliation: Oncogenomic and Epigenetic Unit, IRCCS Regina Elena National Cancer Institute (Italy)

Title: The ID4/mutant p53 protein complex enhances proliferation of breast cancer cells through the modulation of alternative splicing.

Beverly Chilton, PhD

Affiliation: Texas Tech University HSC (United States)

Title: Alternative splicing of helicase-like transcription factor (Hltf) promotes immune tolerance in murine placenta.

Wei Guo, PhD

Affiliation: University of Wisconsin-Madison (USA)

Title: Phosphorylation of RBM20 on RS Domain Plays A Key Role in The Development of Heart Failure.

Dmitri Pervouchine, PhD

Affiliation: Skolkovo Institute of Science and Technology (Russia)

Title: Global cross-regulatory network couples the expression and alternative splicing of RNA-binding proteins by nonsense-mediated mRNA decay.

Sandra Cooper, PhD

Affiliation: The University of Sydney; The Children’s Hospital at Westmead; The Children’s Medical Research Institute (Australia)

Title: Pathogenic Abnormal Splicing Due to Intronic Deletions that Induce Biophysical Space Constraint for Spliceosome Assembly.

Yuichi Shiraishi, PhD

Affiliation: National Cancer Center (Japan)

Title: An atlas of intron retention associated variants collected by cloud-based transcriptome analysis platform.

Logan Walker, PhD

Affiliation: University of Otago (New Zealand)

Title: Assessment of cancer susceptibility gene mRNA splicing with implications for variant classification.

Takuro Miyazaki, PhD

Affiliation: Showa University (Japan)

Title: Defective exon junction complex disturbs cholesterol handling in macrophages thereby exacerbating atherosclerosis.

Mihwa Lee, PhD

Affiliation: La Trobe University (Australia)

Title: Cytoplasmic accumulation of the RNA-binding protein SFPQ by zinc-induced polymerization.

Shalini Sharma, PhD

Affiliation: University of Arizona, College of Medicine-Phoenix (United States)

Title: Impact of Splicing Factor Mutations on Human Hematopoietic Stem and Progenitor Cells.

Dorota Kaminska, PhD

Affiliation: Institute of Public Health and Clinical Nutrition, University of Eastern Finland (Finland)

Title: Obesity and weight loss-related alternative splicing in adipose tissue.

Nicolas Wein, PhD

Affiliation: The Ohio State University (USA)

Title: AAV.U7 induced exon skipping for two mutational hotspots of the DMD gene (~6%) results in efficient exon skipping, protein restoration and force improvement.

Jesús Valdés Flores, PhD

Affiliation: Departamento de Bioquímica, Centro de Investigación y de Estudios Avanzados (Mexico)

Title: Expression of splicing derived circular RNAs in virulent strains of the protozoan parasite Entamoeba histolytica.

Petra Kleiblova, PhD

Affiliation: Charles University, First Faculty of Medicine, Institute of Biology and Medical Genetics (Czech Republic)

Title: NGS-based analyses of RNA as a tool in oncogenetics.

Stephen M. Mount, PhD

Affiliation: Univ. of Maryland (United States)

Title: Yanagi provides fast and interpretable segment-based alternative splicing and gene expression analysis.

Mikhail Skoblov, PhD

Affiliation: Laboratory of Functional Genomics, Research Centre for Medical Genetics (Russia)

Title: Approaches to the analysis of variants affecting splicing in hereditary diseases.

Liliana Florea, PhD

Affiliation: Johns Hopkins University (United States)

Title: High performance tools for analysis of large collections of RNA-seq data.

Gustavo Bressan, PhD

Affiliation: Department of Biochemistry and Molecular Biology – Federal University of Viçosa (Brazil)

Title: Pharmacological intervention of splicing in cancer: targeting the serine/arginine protein kinases (SRPK) to control metastatic melanoma.

Patrick Burgon, PhD

Affiliation: Qatar University (Qatar)

Title: Avaliable soon.

Isaac Edery, PhD

Affiliation: Rutgers University (United States)

Title: Splicing of a thermosensitive intron influences midday siesta via trans-regulation of a nearby oppositely oriented gene.


Affiliation: Texas Southern University, USA

Title: Avaliable soon.